Ukukhishwa kwembewu yamagilebhisii-oligomeric proanthocyanidins, i-bioflavonoid enesakhiwo esikhethekile samangqamuzana, ibonwa njenge-antioxidant yemvelo ephumelela kakhulu emhlabeni.Imbewu yamagilebhisi ekhishwe yimpushana ensundu ngokubomvu, enomoya omncane, ene-astringent, encibilika emanzini kanye nezincibilikisi eziningi eziphilayo.Ukuhlolwa kwabonisa ukuthi amandla okulwa ne-antioxidant wembewu yamagilebhisi akhiphe i-oligomeric proanthocyanidins yayiyizikhathi ezingama-50 zikavithamini E kanye nezikhathi ezingama-20 zikavithamini C, futhi izinga lokumunca lalishesha futhi liphelele.Ngemuva kwemizuzu engama-20, ukuhlushwa okuphezulu kakhulu kwegazi kwafinyelelwa, futhi isigamu sempilo ye-metabolism kwaba amahora ayi-7.

Kukholakala ukuthi empilweni yesimanje abantu banaka kakhulu impilo, igama elithi “Imbewu yamagilebhisi essence oligomeric proanthocyanidins” akayena umuntu ongaziwa kithi.Namuhla, uXiaobian uyeza ukuzokwethula ukusebenza kahle kwe-13 kwembewu yamagilebhisi essence oligomeric proanthocyanidins ikakhulukazi.

1. Umfutho wegazi ophansi kanye ne-cholesterol

Ngokukhula, izintambo ezinwebekayo emithanjeni zizoqina kancane kancane, okuyimbangela ebalulekile yomfutho wegazi ophakeme kubantu asebekhulile.Ukukhishwa kwembewu yamagilebhisi i-oligomeric proanthocyanidins kungakhuphula ukunwebeka kwemithambo yegazi kanye nomfutho wegazi ophansi.Iziguli ezithatha imbewu yamagilebhisi zikhipha ama-oligomeric proanthocyanidins ngemva kwesikhathi esithile, umfutho wegazi uzokwehla kakhulu.Imbewu yamagilebhisi ikhipha i-oligomeric proanthocyanidins inganciphisa i-cholesterol embi, inciphise ukufakwa kwe-cholesterol embi ezindongeni zemithambo yegazi, futhi yehlise umfutho wegazi ngokuvimbela umsebenzi we-reverse transcriptase.

2. Vimbela i-arteriosclerosis, isifo senhliziyo kanye nesifo sohlangothi

Isifo senhliziyo sibalelwa ku-50% inani lokufa kwabantu e-United States minyaka yonke.I-Arteriosclerosis iyisici esibalulekile esibangela isifo senhliziyo.I-arteriosclerosis ingavimba ukugeleza kwegazi, njenge-angina pectoris noma i-myocardial infarction enhliziyweni, ukulahlekelwa inkumbulo noma unhlangothi ebuchosheni.Ikhambi lokulwa nalesi sifo yimbewu yamagilebhisi ekhishwe i-oligomeric proanthocyanidins, esebenzayo futhi ephephile.Akukwazi nje ukuvikela udonga lwangaphakathi lwemithambo yegazi emonakalweni, kodwa futhi kuvimbele ama-platelet ukuthi ahlule futhi enze amahlule egazi, ukuze kuncishiswe ingozi yokushaywa unhlangothi.

3. Umdlavuza

Umphumela wokulwa nomdlavuza wembewu yamagilebhisi ubikwe ephephabhukwini laseMelika iSayensi.Ucwaningo lwesikhathi eside lukhombisile lokhoImbewu yamagilebhisi ikhipha i-oligomeric proanthocyanidinskunganciphisa izinga lezigameko zomdlavuza ohlukahlukene ngokwezinga eliphezulu.Olunye ucwaningo lwabonisa ukuthi izinga lomdlavuza wabantu abanamazinga aphansi kavithamini E laliphindwe izikhathi ezingu-11.4 kunelabantu abavamile.Kodwa-ke, umsebenzi we-antioxidant wembewu yamagilebhisi ekhipha i-oligomeric proanthocyanidins uphindwe izikhathi ezingu-50 kunovithamini E. Imbewu yamagilebhisi ekhipha i-oligomeric proanthocyanidins ingaphinde ivikele amaseli abulala amangqamuzana omdlavuza futhi andise isikhathi somsebenzi wamangqamuzana omdlavuza.

4. Vimbela isilonda

Izinga lokutholakala kwezilonda zesisu liphezulu kakhulu emphakathini wanamuhla.Isizathu esikhulu sezilonda zesisu ukusheshisa kwesigqi sokuphila kwabantu kanye nokwanda kokucindezeleka kwengqondo.Ukuhlala kulesi simo isikhathi eside, ukugcinwa kwe-histamine esiswini kuyanda ngokufanele, okuholela esilonda esiswini.Imbewu yamagilebhisi ekhishwa i-oligomeric proanthocyanidins inciphisa i-histamine, ivikela udonga lwesisu nge-gastric mucosa, inciphise ukuguguleka kwezilonda odongeni lwesisu, ishwabanise indawo yesilonda futhi isize ekwelapheni izilonda.Eminye imishanguzo yesilonda esiswini ikakhulukazi ilapha isilonda esiswini ngokuvimbela ukukhishwa kwe-asidi esiswini, okuvame ukuholela ekuphenduleni okufana ne-dyspepsia.Imbewu yamagilebhisi ikhipha i-oligomeric proanthocyanidins ingavimbela ngempumelelo izilonda ezizenzakalelayo noma zesisu kanye ne-duodenal ebangelwa i-aspirin, ama-steroids kanye nezidakamizwa ze-NSSID.

5. Qeda ubuhlungu be-arthritis nokuvuvukala

Ekuqaleni kwawo-1950, umsebenzi wokulwa nokuvuvukala weamagilebhisi bonad ukukhishwa kwe-oligomeric proanthocyanidins kuye kwaqashelwa.Ingavimbela ukuhlanganiswa nokukhululwa kwezici eziningi zokuvuvukala.Imbewu yamagilebhisi ekhishwa i-oligomeric proanthocyanidins ingahlanganiswa ngokukhetha esicubuni esixhumeneyo samalunga ukuvimbela ukuvuvukala kwamalunga, ukusiza ukuphulukisa izicubu ezilimele futhi kudambise izinhlungu, ngakho-ke i-oligomeric proanthocyanidin ekhishwa yimbewu yamagilebhisi inomphumela obalulekile ezinhlotsheni ezahlukahlukene zesifo samathambo.

6. Thuthukisa i-prostatitis

Ukuvuvukala empeleni kuyinqubo ye-pathological engenzeka kunoma iyiphi ingxenye yomzimba womuntu.Kuyimpendulo yokucindezeleka ekuhlukumezekeni, ukutheleleka kanye nokuvuselela.Kungabonakala ngezimpawu ezihlukahlukene, njengokubomvu, ubuhlungu, umkhuhlane kanye nokungasebenzi kahle.I-Prostatitis yisifo esivamile emadodeni.Kuyisifo sokuvuvukala esibangelwa ukungasebenzi kahle kwe-prostate ngaphansi kwesenzo se-prostaglandin PGE2.Imbewu yamagilebhisi ikhipha i-oligomeric proanthocyanidins ingathuthukisa izimpawu ze-prostatitis futhi ithuthukise izinga lempilo yeziguli ze-prostate ngokuvimbela ukukhululwa kwe-PGE2.

7. Vimbela ukungezwani komzimba

I-antianaphylaxis yembewu yamagilebhisi ekhishwe i-oligomeric proanthocyanidins ihlobene nomphumela wayo we-antihistamine.Kunezinhlobo ezimbili zamaseli emzimbeni womuntu abizwa ngokuthi ama-basophil nama-mast cell, aqukethe izinto ezithile ezizwelayo.Ama-radicals wamahhala asebenza kulwelwesi lwamaseli alawa maseli amabili, okuholela ekuqhekekeni kwamaseli nokukhululwa kwezinto ezizwelayo.Lapho umzimba uhlangana nezinye izinto ezingezwani nangaphandle, njengempova, uthuli, izidakamizwa, amaprotheni angaphandle (njengezinhlanzi, izimfanzi nokunye ukudla kwasolwandle), izimpawu zokungezwani komzimba ziyoba khona.Ngokungafani nezinye izidakamizwa ezilwa nokuvuvukala ezivame ukusetshenziswa, i-oligomeric proanthocyanidins ekhishwe imbewu yamagilebhisi ayisebenzi nje kuphela, kodwa futhi ayinayo imiphumela emibi efana nokukhathala, ukucindezeleka, nokunye, okungeke kuthinte umsebenzi ovamile nokuphila.

8. Vikela ubuchopho

Imbewu yamagilebhisi iyona kuphela i-antioxidant enganikeza isivikelo kumaseli wobuchopho ngokusebenzisa umgoqo wegazi nobuchopho.Ngakho-ke, kungavimbela isifo i-Alzheimer's.Ngaphezu kwalokho, ingakwazi futhi ukuzinzisa umgoqo wegazi nobuchopho futhi ivimbele izinto eziyingozi nezinobuthi ukuthi zingangeni ebuchosheni, ukuze zivikele ubuchopho.

9. Ukuvimbela nokwelashwa kwesifuba somoya kanye ne-emphysema

Imbewu yamagilebhisi ekhishwe i-oligomeric proanthocyanidins iyinzuzo ezigulini ezinesifuba somoya kanye ne-emphysema.I-asthma ibangelwa kakhulu ukungezwani komzimba ku-bronchus.Imbewu yamagilebhisi ekhishwa i-oligomeric proanthocyanidins ingavimbela ukukhiqizwa kwe-histamine nezinye izinto ezingezwani nomzimba, ngakho iphumelela kakhulu ekuvimbeleni nasekwelapheni isifuba somoya.Imbewu yamagilebhisi ikhipha i-oligomeric proanthocyanidins iphinde inciphise izimpawu ezihlobene ne-emphysema, njengokukhwehlela, ubuthakathaka, amafinyila kanye nezifo zepheshana lokuphefumula.

10. Ukuvimbela i-cataract kanye ne-glaucoma

Abalandeli be-TV nabalandeli bamakhompiyutha abahlala phambi kwesikrini isikhathi eside bazobhekana nokulimala okunamandla kwemisebe emehlweni abo, okuwumonakalo omkhulu wama-radicals mahhala kumalensi abo kanye ne-retina.E-United States, abantu abangaba ngu-40 000 abayizimpumputhe ngenxa ye-cataract minyaka yonke.Imbewu yamagilebhisi isusa ama-radicals mahhala emzimbeni futhi ivimbele ukufakwa kwe-oxidation yama-radicals mahhala kumaprotheni e-lens, ukuze kuvinjwe ukuvela kwe-cataract.Imbewu yamagilebhisi ekhishwe i-oligomeric proanthocyanidins ingathuthukisa kakhulu ukumelana nemithambo, inciphise ukungeneka kwemithambo, ngaleyo ndlela ivimbele ukuvuza kwezinye izinto egazini, futhi ivimbele ukuvela kwe-retinitis yesifo sikashukela.

I-glaucoma ibangelwa ukucindezela okukhulu kwe-intraocular.Imbewu yamagilebhisi ekhishwa ama-oligomeric proanthocyanidins kulula ukubopha nge-collagen, ukuze umonakalo omkhulu wamahhala ku-collagen uqedwe ngokukhishwa kwembewu yamagilebhisi i-oligomeric proanthocyanidins ngaphambi kokuthi ivikele i-glaucoma.Eqinisweni, imbewu yamagilebhisi ikhipha i-oligomeric proanthocyanidins ingaphinda ilungise i-collagen eyonakaliswe ama-radicals wamahhala, ngakho-ke i-oligomeric proanthocyanidins ekhishwe imbewu yamagilebhisi ingasetshenziswa futhi ukwelapha i-glaucoma.

11. Vikela ngempumelelo amazinyo nezinsini

I-caries yamazinyo ibangelwa amagciwane e-cariogenic emlonyeni.Leli gciwane lingakwazi ukubola ushukela ukuze likhiqize i-asidi, ukuze ligqwese amazinyo, lakhe izimbobo ze-caries, liveze imizwa yamazinyo ngaphakathi, futhi lenze abantu ubuhlungu obungabekezeleleki.Kodwa-ke, amabhaktheriya e-cariogenic angadlala indima yawo ye-cariogenic kuphela ngokunamathisela inkimbinkimbi ye-fibrin kumqhele noma ngaphezulu kwezinyo.Imbewu yamagilebhisi ikhipha i-oligomeric proanthocyanidins ingabophezela kulo mcu weprotheni, iwavimbele ekubopheni enze i-plaque futhi anamathele emazinyweni awo, ukuze amagciwane e-cariogenic alahlekelwe "indawo eyisisekelo".Ngaphansi kokugezwa kwamathe emlonyeni, amagciwane awakwazi ukunamathela emazinyweni isikhathi eside, ngakho awakwazi ukubolisa ushukela ukuze akhiqize i-asidi yokugqwala amazinyo.

12. Yehlisa ukungezwani komzimba ngaphambi kokuya esikhathini

Izimpawu ezivamile ze-premenstrual tension syndrome yilezi: ubuhlungu bokuya esikhathini, ukuvuvukala kwebele, ukungakhululeki kwesisu, ukuqunjelwa kobuso, ubuhlungu obungaqinisekile be-pelvic, ukuzuza isisindo, ukungasebenzi kahle kwe-endocrine, ukungazinzi ngokomzwelo, ukujabula, ukucasuka, ukucindezeleka kanye nekhanda elibuhlungu lemizwa.Ukukhishwa kwembewu yamagilebhisi i-oligomeric proanthocyanidins kungadambisa ukungezwani kokuya esikhathini ngokusebenzisa izakhiwo ezilwa nokungezwani komzimba.

13. Ukungagugi

Emazweni aseYurophu naseMelika, i-oligomeric proanthocyanidins yembewu yamagilebhisi aziwa ngokuthi "amavithamini esikhumba" kanye "nezimonyo zomlomo".Ziyimikhiqizo yobuhle edumile yabesifazane bayo yonke iminyaka.

Isikhumba sicebile izicubu ezixhumene, eziqukethe i-collagen ne-elastin, edlala indima ebalulekile kuso sonke isakhiwo sesikhumba.Lokhu buqotho kuncike kulokho okubizwa ngokuthi "i-collagen cross-linking" - i-collagen yakha ama-microfibrils, futhi ama-microfibril amabili axhunyiwe, njengeladi.I-crosslinking emaphakathi iyadingeka ngoba ngale ndlela kuphela kungagcinwa ubuqotho besakhiwo sesikhumba.Kodwa-ke, i-radical oxidation yamahhala ingabangela ukuwela ngokweqile, okwenza lesi sakhiwo sibe lukhuni futhi sibe brittle.Esikhumbeni, lokhu kuphambana okweqile kubonakala njengemibimbi nama-vesicles.

Ukukhishwa kwembewu yamagilebhisi i-oligomeric proanthocyanidins idlala indima embaxambili lapha: ngakolunye uhlangothi, ingakhuthaza ukwakheka kokuxhumanisa okufanele kwe-collagen.Ngakolunye uhlangothi, njenge-free radical scavenger esebenzayo, ingavimbela ukwenzeka "kokuxhumanisa ngokweqile".Ngakho-ke, ivimbela ukubonakala kwemibimbi yesikhumba nama-vesicles futhi igcina isikhumba sithambile futhi sibushelelezi.

Okwenza isikhumba sinwebeka kungenye ingxenye yesikhumba - i-elastin eqinile.I-elastin eqinile ingonakaliswa ngomonakalo wama-radical wamahhala noma i-elastase.Isikhumba esingenayo i-elastin eqinile sikhululekile futhi sibuthakathaka, okwenza abantu babukeke bebadala.Ama-radicals wamahhala avimba ukukhiqizwa kwe-elastin eqinile futhi avimbele umsebenzi wayo.Imbewu yamagilebhisi ikhipha i-oligomeric proanthocyanidin isusa ama-radicals mahhala futhi ithuthukise impilo yesikhumba ngaphakathi.Yingakho imbewu yamagilebhisi i-oligomeric proanthocyanidins eyaziwa ngokuthi "amavithamini esikhumba" kanye "nezimonyo zomlomo".