Huperzine A
[Igama lesiLatini]I-Huperzia serratum
[Umthombo] I-Huperziceae yonke imifino evela e-China
[Ukubukeka]Onsundu ukuya kokumhlophe
[Isithako]Huperzine A
[Ukucaciswa]Huperzine A1% - 5%, HPLC
[Ukunyibilika] Incibilika ku-chloroform, i-methanol, i-ethanol, inyibilika kancane emanzini
[Usayizi wezinhlayiyana] 80 Mesh
[Ukulahlekelwa lapho omiswa] ≤5.0%
[Insimbi Esindayo] ≤10PPM
[Izinsalela zezibulala-zinambuzane] EC396-2005, USP 34, EP 8.0, FDA
[Isitoreji] Gcina endaweni epholile neyomile, gwema ukukhanya nokushisa okuqondile.
[Impilo yeshelufu] Izinyanga ezingama-24
[Iphakheji] Ipakishwe ngezigubhu zephepha kanye nezikhwama zepulasitiki ezimbili ngaphakathi.
[Iyini i-Huperzine A]
I-Huperzia uhlobo lobulembu obumila eShayina.Ihlobene ne-club mosses (umndeni we-Lycopodiaceae) futhi yaziwa kwezinye izazi zezitshalo ngokuthi i-Lycopodium serratum.I-moss yonke elungisiwe yayisetshenziswa ngokwesiko.Amalungiselelo amakhambi esimanje asebenzisa kuphela i-alkaloid engayodwa eyaziwa ngokuthi i-huperzine A. I-Huperzine A iyi-alkaloid etholakala ku-huperzia okuye kwabikwa ukuthi ivimbela ukuwohloka kwe-acetylcholine, into ebalulekile edingwa isimiso sezinzwa ukuze sidlulisele ukwaziswa kusuka kungqamuzana ukuya kungqamuzana.Ucwaningo lwezilwane luphakamise ukuthi ikhono le-huperzine A lokulondoloza i-acetylcholine lingase libe likhulu kuneleminye imithi kadokotela.Ukulahlekelwa ukusebenza kwe-acetylcholine kuyisici esiyinhloko sokuphazamiseka okuningana kokusebenza kobuchopho, okuhlanganisa nesifo i-Alzheimer's.I-Huperzine A ingase futhi ibe nomthelela ovikelayo ezicutshini zobuchopho, iqhubeke ikhulise amandla ayo etiyetha okusiza ukwehlisa izimpawu zokuphazamiseka okuthile kobuchopho.
[Umsebenzi] Isetshenziswa kwezinye izindlela zokwelapha, i-huperzine A itholakale isebenza njenge-cholinesterase inhibitor, uhlobo lomuthi olusetshenziselwa ukuvimbela ukuwohloka kwe-acetylcholine (ikhemikhali ebalulekile ekufundeni nasekukhumbuleni).
Ayisetshenziswa nje kuphela njengokwelapha isifo i-Alzheimer's, i-huperzine A kuthiwa ithuthukisa ukufunda nenkumbulo futhi ivikele ekuwohlokeni komqondo okuhlobene neminyaka.
Ngaphezu kwalokho, i-huperzine A ngezinye izikhathi isetshenziselwa ukuqinisa amandla, ukwandisa ukuphaphama, nokusiza ekwelapheni i-myasthenia gravis (isifo sokuzivikela komzimba esithinta imisipha).
