Huperzine A
[Igama lesiLatini]Huperzia serratum
[Umthombo] Huperziceae yonke imifuno evela eTshayina
[Imbonakalo] Brown ukuya mhlophe
[Isithako]Huperzine A
[Inkcazo]Huperzine A1% - 5%, HPLC
[Ukunyibilika] Inyibilika kwichloroform, methanol, ethanol, inyibilika kancinane emanzini.
[Ubungakanani besuntswana] 80 Mesh
[Ilahleko ekomisweni] ≤5.0%
[Intsimbi enzima] ≤10PPM
[Intsalela yesitshabalalisi] EC396-2005, USP 34, EP 8.0, FDA
[Ugcino] Gcina kwindawo epholileyo neyomileyo, gcina kude nokukhanya okuthe ngqo kunye nobushushu.
[Ubomi beShelufu] Iinyanga ezingama-24
[Ipakethi] Ipakishwe ngamadubhu ephepha kunye neengxowa ezimbini zeplastiki ngaphakathi.
[Yintoni iHuperzine A]
IHuperzia luhlobo lobulembu obukhula eTshayina.Inxulumene nobulembu beeklabhu (usapho lweLycopodiaceae) kwaye yaziwa kwezinye iingcali ngezityalo njengeLycopodium serratum.I-moss yonke elungisiweyo yayisetyenziswe ngokwesiko.Amalungiselelo amayeza anamhlanje asebenzisa kuphela i-alkaloid ekwanti eyaziwa ngokuba yi-huperzine A. I-Huperzine A yi-alkaloid efumaneka kwi-huperzia eye yaxelwa ukunqanda ukuchithwa kwe-acetylcholine, into ebalulekileyo efunekayo yinkqubo ye-nervous yokuhambisa ulwazi kwiseli ukuya kwiseli.Uphando lwezilwanyana lucebise ukuba amandla e-huperzine A okugcina i-acetylcholine inokuba mkhulu kunezinye izidakamizwa ezichazwe ngugqirha.Ukulahlekelwa ngumsebenzi we-acetylcholine luphawu oluphambili lweengxaki ezininzi zokusebenza kwengqondo, kuquka nesifo se-Alzheimer.I-Huperzine A inokuba nefuthe elikhuselayo kwizicubu zobuchopho, inyuse ngakumbi amandla ayo okucinga ukunceda ukunciphisa iimpawu zokuphazamiseka kwengqondo.
[Umsebenzi] Isetyenziswe kunyango olulolunye, i-huperzine A ifunyenwe isebenza njenge-cholinesterase inhibitor, uhlobo lweyeza elisetyenziselwa ukuthintela ukuchithwa kwe-acetylcholine (ikhemikhali ebalulekileyo ekufundeni nasekukhumbuleni).
Ayisetyenziswanga kuphela njengonyango lwe-Alzheimer's, i-huperzine A ikwatsho ukuba iphucule ukufunda kunye nenkumbulo kunye nokukhusela ekunciphiseni kwengqondo okunxulumene nobudala.
Ukongezelela, i-huperzine A ngamanye amaxesha isetyenziselwa ukunyusa amandla, ukwandisa ukuphaphama, kunye nokunceda unyango lwe-myasthenia gravis (i-autoimmune disorder echaphazela imisipha).