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5-HTP is a chemical compound that is naturally produced in your body as it makes serotonin, an important hormone for regulating your mood. Some doctors consider 5-HTP to be the best natural appetite suppressant. 5-HTP is also naturally produced in various plants, including the seeds of griffonia simplicifolia, a West African shrub. In addition to suppressing your appetite, there is some research that suggests that 5-HTP can also help treating headaches, insomnia, and depression.

5-HTP has been studied for over 30 years. Several clinical trials have shown that it works to lower the number of calories eaten and aids in weight loss.One study compared overweight women who took 200 mg of 5-HTP before each meal to those who took a placebo. The women who took the supplement ate 1,084 fewer calories per day and felt less hungry during the day. In another study, women who took 5-HTP lost 10.3 pounds over 12 weeks, compared to 2.2 pounds in the placebo group.

Experts and researchers agree that 5-HTP works best for those who constantly crave food around the clock – especially carbs.