[Latin Name] Hypericum perforatum

[Plant Source] From China

[Appearance] Brown fine powder

[Specifications] 0.3% Hypericin

[Particle size] 80 Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Pesticide residue] EC396-2005, USP 34, EP 8.0, FDA

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Package] Packed in paper-drums and two plastic-bags inside.

[What is St. John's wort]

St. John’s wort (Hypericum perforatum) has a history of use as a medicine dating back to ancient Greece, where it was used for a range of illnesses, including various nervous disorders. St. John’s wort also has antibacterial, antioxidant, and antiviral properties. Because of its anti-inflammatory properties, it has been applied to the skin to help heal wounds and burns. St. John’s wort is one of the most commonly purchased herbal products in the United States.

In recent years, St. John’s wort has been studied extensively as a treatment for depression. Most studies show that St. John’s wort may help treat mild-to-moderate depression, and has fewer side effects than most other prescription antidepressants.

[Functions]

1. Anti-depressive and sedative properties;

2. Effective remedy for the nervous system, relaxing tension, and anxiety and lifting the spirits;

3. Anti-inflammatory

4. Improve capillary circulation

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Ph.D. mentor: Prof. Ravi S. Kane, P. K. Lashmet Professor and Dept. Head of Chemical and Biochemical Engineering at RPI
Ph.D. committee members: Prof. Peter M. Tessier, RPI CHBE; Prof. Steven M. Cramer, RPI CHBE; Prof. Shekhar Garde, RPI CHBE and Dean of Engineering; Prof. Marlene Belfort, SUNY Albany Biological Sciences

Dissertation Title: The design of multivalent conjugates for anthrax toxin, influenza, and HIV inhibition

When proteins, peptides, oligonucleotides, or polysaccharides are strategically arranged on biocompatible scaffolds, the activity of such molecules can be profoundly affected. Creating multivalent arrangements, which involve the simultaneous interaction of multiple binding elements with multiple target receptors, can be a powerful method for enhancing the efficacy of bioactive molecules. For example, one can synthesize multivalent ligands that enhance receptor binding affinities by several orders of magnitude over the corresponding monovalent receptor-ligand interaction. In this talk, I will describe my research on various structure-based designs of multivalent macromolecular conjugates for the effective inhibition of three different pathogens with broad public interest: anthrax, HIV, and influenza. Identifying conserved targets in the pathogenic progression of each of these is a key aspect of this research, and once appropriate targets have been identified, using strategically-designed scaffolds to control the multivalent arrangements of targeting ligands is crucial. Indeed, achieving precise control over the display of biologically relevant ligands may be the key to understanding mechanisms driving a diverse set of biological processes ranging from the inhibition of pathogenicity to effecting stem cell differentiation. Therefore, the study of multivalent complexes such as these has the potential to lead to very promising therapeutic applications.