[Latin Name] Sambucus nigra

[Specification] Anthocyanidins15% 25% UV

[Appearance] Purple fine powder

Plant Part Used: Fruit

[Particle size] 80Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Storage] Store in cool & dry area, keep away from the direct light and heat.

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

[What is elderberry extract?]

Elderberry extract comes from the fruit of the Sambucus nigra or Black Elder, a species found in Europe, Western Asia, North Africa, and North America. Called “the medicine chest of the common people,” Elder flowers, berries, leaves, bark, and roots have all been used for centuries in traditional folk medicines.Elder fruit contains vitamins A, B and C, flavonoids, tannins, carotenoids, and amino acids. Elderberry is believed to possess therapeutic uses as an anti-inflammatory, diuretic, and immuno-stimulant.

[Function]

1. As medicine raw material: It can promote the healing of gastrointestinal ulcers; It can be used for acute and chronic hepatitis and hepatitis evocable hepatomegaly, hepatocirrhosis; promote the healing of liver function.

2. As foodstuff colorant: Widely used in cakes, beverage, candy, ice cream etc..

3. As chemical raw material for daily use: Widely used in many kinds of green medicine toothpastes and cosmetics.

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Milk Thistle (Silybum marianum) is a European herb, with more than 2000 years of human consumption, used traditionally for liver disease, but is it actually effective? Find out here!

Scientific Literature:

Bosch-Barrera, J., & Menendez, J. A. (2015). Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy. Cancer Treatment Reviews, 41(6), 540-546. – https://www.ncbi.nlm.nih.gov/pubmed/25944486

Bosch-Barrera, J., Sais, E., Cañete, N., Marruecos, J., Cuyàs, E., Izquierdo, A., … Menendez, J. A. (2016). Response of brain metastasis from lung cancer patients to an oral nutraceutical product containing silibinin. Oncotarget, 7(22), 32006–32014. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077992/pdf/oncotarget-07-32006.pdf

Freedman, N. D., Curto, T. M., Morishima, C., Seeff, L. B., Goodman, Z. D., Wright, E. C., … the HALT-C Trial Group. (2011). Silymarin use and liver diease progression in the HALT-C trial. Alimentary Pharmacology & Therapeutics, 33(1), 127–137. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490214/pdf/nihms415758.pdf

Freitag, A. F., Cardia, G. F. E., da Rocha, B. A., Aguiar, R. P., Silva-Comar, F. M. de S., Spironello, R. A., … Cuman, R. K. N. (2015). Hepatoprotective effect of silymarin (Silybum marianum) on hepatotoxicity induced by acetaminophen in spontaneously hypertensive rats. Evidence-Based Complementary and Alternative Medicine : eCAM, 2015, 538317. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363982/pdf/ECAM2015-538317.pdf

Hong, M., Li, S., Tan, H. Y., Wang, N., Tsao, S.-W., & Feng, Y. (2015). Current status of herbal medicines in chronic liver disease therapy: The biological effects, molecular targets and future prospects. International Journal of Molecular Sciences, 16(12), 28705–28745. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691073/pdf/ijms-16-26126.pdf

Kawaguchi-Suzuki, M., Frye, R. F., Zhu, H.-J., Brinda, B. J., Chavin, K. D., Bernstein, H. J., & Markowitz, J. S. (2014). The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Drug Metabolism and Disposition, 42(10), 1611–1616. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/pdf/dmd.114.057232.pdf

Kumar, R., Deep, G., & Agarwal, R. (2015). An overview of ultraviolet B radiation-induced skin cancer chemoprevention by silibinin. Current Pharmacology Reports, 1(3), 206–215. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471873/pdf/nihms-672250.pdf

Lazzeroni, M., Guerrieri-Gonzaga, A., Gandini, S., Johansson, H., Serrano, D., Cazzaniga, M., … & Bonanni, B. (2016). A presurgical study of oral silybin-phosphatidylcholine in patients with early breast cancer. Cancer Prevention Research, 9(1), 89-95. – https://cancerpreventionresearch.aacrjournals.org/content/canprevres/9/1/89.full.pdf

Schrieber, S. J., Hawke, R. L., Wen, Z., Smith, P. C., Reddy, K. R., Wahed, A. S., … Fried, M. W. (2011). Differences in the disposition of silymarin between patients with nonalcoholic fatty liver disease and chronic hepatitis C. Drug Metabolism and Disposition, 39(12), 2182–2190. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226378/pdf/zdd2182.pdf

Surai, P. F. (2015). Silymarin as a natural antioxidant: An overview of the current evidence and perspectives. Antioxidants, 4(1), 204–247. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665566/
Yang, Z., Zhuang, L., Lu, Y., Xu, Q., & Chen, X. (2014). Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: A meta-analysis of randomized controlled trials. BioMed Research International, 2014, 941085. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163440/pdf/BMRI2014-941085.pdf

Wu, J.-P., Tsai, C.-C., Yeh, Y.-L., Lin, Y.-M., Lin, C.-C., Day, C. H., … Huang, C.-Y. (2015). Silymarin accelerates liver regeneration after partial hepatectomy. Evidence-Based Complementary and Alternative Medicine : eCAM, 2015, 603529. – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539063/pdf/ECAM2015-603529.pdf

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