[Latin Name] Vitis vinifera L.

[Plant Source]from China

[Specifications]Proanthocyanidins polyphenol

[Appearance]Purple red fine powder

Plant Part Used:Skin

[Particle size] 80 Mesh

[Loss on drying] ≤5.0%

[Heavy Metal] ≤10PPM

[Pesticide residue] EC396-2005, USP 34, EP 8.0, FDA

[Shelf life] 24 Months

[Package] Packed in paper-drums and two plastic-bags inside.

[Net weight] 25kgs/drum

Function

1.Grape skin extract used to reduce cancer risk;

2.Grape skin extract has the useage of antioxidant activity;

3.Grape skin extract has anti-inflammatory, removal of swollen;

4.Grape skin extract can reduce the incidence of spots and cataracts;

5.Grape skin extract will reduced exercise-induced vascular sclerosis porridge;

6.Grape skin extract will strengthen the blood vessels the flexibility of the wall.

Application

1.Grape skin extract can be made into capsules, troche and granule as healthy food;

2.High quality grape skin extract has been widely added into the beverage and the wine, cosmetics as the functional content;

3. Grape skin extract is widely added into all kinds of foods such as cake, cheese as the nurture, natural antiseptic in Europe and USA, and it has increased the safety of the food.

What is Grape Skin extract?

Grape skin extract are industrial derivatives from whole grape seeds that have a great concentration of vitamin E, flavonoids, linoleic acid, and OPCs. Typically, the commercial opportunity of extracting grape seed extract constituents has been for chemicals known as polyphenols, including oligomeric proanthocyanidins recognized as antioxidants.

Grape skin extract is rich in Oligomers Procyanidin Complexes (OPC) , which is a powerful antioxidant. In addition to the ultra rich potence of over 20 times higher than Vitamin C. Grape skin extract is also 50 times better than Vitamin E. Grape skin extract helps to strengthen the immune system, and also slowdown the aging process, which is of very high market value. Procyanidin B2, which is the most active compound to neutralize free radicals that cause aging, is available only in Grape Seed.

In Europe, OPC from grape skin extract proanthocyanidins has been adopted and used for several decades as a safe and effective compound. Grape skin extract has no record of any acute or chronic toxicity, no harmful reaction even under very high dosage. For these reasons, grape skin extract proanthocyanidins has become a new star in the food supplement market.

Titre du document / Document title
Cytotoxic activity of Justicia spicigera is inhibited by bcl-2 proto-oncogene and induces apoptosis in a cell cycle dependent fashion
Auteur(s) / Author(s)
CACERES-CORTES J. R. (1) ; CANTU-GARZA F. A. (2) ; MENDOZA-MATA M. T. (3) ; CHAVEZ-GONZALEZ M. A. (1) ; RAMOS-MANDUJANO G. (1) ; ZAMBRANO-RAMIREZ I. R. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Research Unit of Cell Differentiation and Cancer, Faculty of Professional Studies-Zaragoza, National Autonomous University of Mexico, FES-Zaragoza, UNAM, MEXIQUE
(2) Chemistry Engineering Department, Faculty of Professional Studies-Zaragoza, National Autonomous University of Mexico, FES-Zaragoza, UNAM, ESPAGNE
(3) Pharmacology Department, Faculty of Professional Studies-Zaragoza, National Autonomous University of Mexico, FES-Zaragoza, UNAM, ESPAGNE

Résumé / Abstract
Identification of organic compounds from plants is of clinical significance because of the effect that they might have in patients with haematopoietic disorders. We studied the effect of the plant extract Justicia spicigera (Acanthaceae) in different haematopoietic cells: human leukaemic cell lines, umbilical cord blood cells, and mouse bone marrow cells. By examining colony formation and performing the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay it was shown that the plant extract of Justicia spicigera contains cytotoxic factors for leukaemic cells and has no proliferative activity on normal haematopoietic progenitor cells. Our results show that this plant extract induces apoptosis in the human leukaemia cell line TF-1, but not in the bcl-2 transfectant cell line TB-1. Similar results were obtained using a haemopoietic cell line 32D and 32DBcl2. The cultures of umbilical cord blood cells and mouse bone marrow that contain granulocyte-macrophage colony-stimulating factor (GM-CSF) do not proliferate or become terminally differentiated in the presence of the infusion of Justicia spicigera. GM-CSF that acts by abrogating programmed cell death is not sufficient to inhibit the apoptotic stimulus in TF-1 and 32D cells. Moreover mouse fibroblasts (3T3) and two cervical carcinoma cell lines CALO and INBL, undergo apoptosis in the presence of different concentrations of an infusion from the plant. Our data show that there is a strong correlation between the cytotoxic effect and cell proliferation. Together, these results indicate that the plant infusion of Justicia spicigera does not contain any haematopoietic activity, induces apoptosis inhibited by bcl-2 and is linked to cell proliferation.
Revue / Journal Title
PTR. Phytotherapy research ISSN 0951-418X
Source / Source
2001, vol. 15, no8, pp. 691-697 (24 ref.)
Langue / Language
Anglais

Editeur / Publisher
Wiley, Chichester, ROYAUME-UNI (1987) (Revue)

Mots-clés anglais / English Keywords
America ; Central America ; Spermatophyta ; Angiospermae ; Dicotyledones ; Acanthaceae ; Mexico ; Folk medicine ; Pharmacognosy ; Animal ; Human ; Apoptosis ; In vitro ; Cell proliferation ; Antineoplastic agent ; Tumor cell ; Biological activity ; Cytotoxicity ; Plant origin ; Medicinal plant ;

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